Mycobacteria and TB

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Rapid speciation of mycobacteria with simultaneous detection of MDR tB

Background Multidrug resistance (MDR) TB is on the rise globally and is associated with significant morbidity and mortality. Conventional culture based drug susceptibility testing (DST) for TB drugs is time consuming, leading to diagnostic delays contributing to higher TB morbidity and mortality and exacerbation of ongoing transmission. Moreover most of the NTM(Non tuberculous mycobacteria) tha...

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Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB.

Limited performance data from line probe assays (LPAs), nucleic acid tests used for the rapid diagnosis of tuberculosis (TB), nontuberculosis mycobacteria (NTM), and Mycobacterium tuberculosis drug resistance are available for HIV-infected individuals, in whom paucibacillary TB is common. In this study, the strategy of testing sputum with GenoType MTBDRplus (MTBDR-Plus) and GenoType Direct LPA ...

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Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST.

OBJECTIVES To assess the predictive value of in vitro drug susceptibility testing (DST) in slow-growing non-tuberculous mycobacteria (NTM), knowledge on quantitative levels of drug susceptibility should be available. The aim of this study was to investigate the suitability of the MGIT 960/TB eXiST system for quantitative DST of NTM. METHODS We have assessed quantitative levels of drug suscept...

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Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

The prevalence of lung disease due to infections with nontuberculous mycobacteria (NTM) has been increasing and surpassed tuberculosis (TB) in some countries. Treatment outcomes are often unsatisfactory, highlighting an urgent need for new anti-NTM medications. Although NTM in general do not respond well to TB specific drugs, the similarities between NTM and Mycobacterium tuberculosis at the mo...

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ژورنال

عنوان ژورنال: Revista do Instituto de Medicina Tropical de São Paulo

سال: 2002

ISSN: 0036-4665

DOI: 10.1590/s0036-46652002000600011